World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Hypoxia Modulates Infection of Epithelial Cells by Pseudomonas Aeruginosa, Volume 7

By Karhausen, Jörn

Click here to view

Book Id: WPLBN0003938848
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Hypoxia Modulates Infection of Epithelial Cells by Pseudomonas Aeruginosa, Volume 7  
Author: Karhausen, Jörn
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos

Description : Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen commonly associated with lung and wound infections. Hypoxia is a frequent feature of the microenvironment of infected tissues which induces the expression of genes associated with innate immunity and inflammation in host cells primarily through the activation of the hypoxia-inducible factor (HIF) and Nuclear factor kappaB (NF-kB) pathways which are regulated by oxygen-dependent prolyl-hydroxylases. Hypoxia also affects virulence and antibiotic resistance in bacterial pathogens. However, less is known about the impact of hypoxia on host-pathogen interactions such as bacterial adhesion and infection. In the current study, we demonstrate that hypoxia decreases the internalization of P. aeruginosa into cultured epithelial cells resulting in decreased host cell death. This response can also be elicited by the hydroxylase inhibitor Dimethyloxallyl Glycine (DMOG). Reducing HIF-2a expression or Rho kinase activity diminished the effects of hypoxia on P. aeruginosa infection. Furthermore, in an in vivo pneumonia infection model, application of DMOG 48 h before infection with P. aeruginosa significantly reduced mortality. Thus, hypoxia reduces P. aeruginosa internalization into epithelial cells and pharmacologic manipulation of the host pathways involved may represent new therapeutic targets in the treatment of P. aeruginosa infection.


Click To View

Additional Books

  • Plos One : a Pig Model of the Preterm Ne... (by )
  • Plos One : Extracellular Atp Released by... (by )
  • Plos One : Collapse of a Marine Mammal S... (by )
  • Plos One : Population Pk, Volume 7 (by )
  • Plos One : an Erp Study of Good Producti... (by )
  • Plos One : Novel Compound Heterozygous T... (by )
  • Plos One : New Indices for Predicting Gl... (by )
  • Plos One : Short Placental Telomere Was ... (by )
  • Plos One : Profiling Epidermal Growth Fa... (by )
  • Plos One : Explicating the Face Percepti... (by )
  • Plos One : High Levels of Asymmetric Dim... (by )
  • Plos One : Differential Requirement for ... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.