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Oncogene Activation in Spontaneous and Chemically Induced Rodent Tumors : Implications for Risk Analysis

By Reynolds, Steven H.

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Book Id: WPLBN0000196622
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005

Title: Oncogene Activation in Spontaneous and Chemically Induced Rodent Tumors : Implications for Risk Analysis  
Author: Reynolds, Steven H.
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Reynolds, S. H. (n.d.). Oncogene Activation in Spontaneous and Chemically Induced Rodent Tumors : Implications for Risk Analysis. Retrieved from http://worldlibrary.net/


Description
Government Reference Publication

Excerpt
Excerpt: Several approaches have been used to identify environmental agents posing significant carcinogenic hazards to man. These include in uifro assays for mutagenesis and in vivo tumorigenicity assays. However, most chemicals are classified as potentially hazardous to humans on the basis of long-term carcinogenesis studies in rodents. While these rodent carcinogenesis studies are designed to mimic the route of human exposure in the environment or workplace, the dose of a given chemical is usually higher than that which actually occurs in human exposure. The extrapolation of rodent carcinogenic data to human risk is therefore complicated by the higher doses of chemicals that are employed in the rodent bioassays, especially in the absence of information regarding the mechanism(s) of tumor induction.

 

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